Graham Kaye was born in Canberra where he completed his schooling before undertaking his medical studies at the University of Sydney, graduating in 1977. He completed his internship and residency at Royal Prince Alfred Hospital in Sydney before returning to Canberra where he started his specialist training at Royal Canberra and Woden Valley Hospitals. After obtaining his Fellowship to the Royal Australasian College of Physicians he completed his training in Gastroenterology and Hepatology at the renowned Royal Free Hospital in London. In 1991 he returned to Canberra where he joined gastrotrACT.

Currently Dr Kaye is a consultant Gastroenterologist and Hepatologist at gastrotrACT in Canberra, A.C.T. He is also a Visiting Medical Officer of Gastroenterology at the Canberra Hospital and teaches at the Canberra Clinical School and the University of Sydney. Dr Kaye also consults as a Physician and Gastroenterologist at the John James Memorial Hospital, the National Capital Private Hospital and Calvary Public and Private Hospitals, Canberra, ACT.